E. coli Nissle 1917 probiotic

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Mutaflor 100 capsules

Mutaflor is registered in Australia for the relief and management of chronic constipation. Your healthcare practitioner may also utilise this strain for its pharmacological, metabolic and immunomodulation properties.

Strain-Specific Characteristics of Escherichia coli strain Nissle 1917.

The ability to colonize

Antagonistic activity, Inhibition of growth and or killing of pathogens

Anti-invasive, prevention of colonisation in the gut by pathogens

Synthesis of endogenous antimicrobial peptides-defensins

Mucosal integrity, contributing to luminal metabolism and stability of intestinal milieu-enhanced epithelial barrier function

Anti-inflammatory and immunomodulatory effects

Stimulation of colonic mucosa

Servings per box: 100 capsules

Directions for use Adults: The usual dosage of Mutaflor for Chronic Constipation in adults is: 3 to 4 capsules of Mutaflor per day.Please note that your health care professional may suggest alternative dosing specific to your situation.

Allergen Information Does not contain any milk proteins, gluten, wheat or lactose.

Mutaflor Ingredients:1 gastro-resistant hard capsule of Mutaflor contains 2.5 to 25 x 10^9 viable cells (CFU) of Escherichia coli Nissle 1917. The bacteria is lyophilized and filled into hard gelatine capsules which are enteric coated in order to open up when the terminal ileum is reached.Mutaflor should be stored refrigerated from 2 to 8 °C. A short interruption of refrigeration (3 or 4 days) does not do any harm to the product.

Product Education:

The origins of Mutaflor are somewhat less than auspicious. First isolated in 1917 from the faeces of a soldier in World War One who did not succumb to dysentery unlike most of his other comrades in regions that were highly contaminated by enteropathogens.

Mutaflor still today contains this very Nissle strain but manufactured in a modern GMP facility, lyophilized or freeze-dried, a process to remove moisture whilst the strain remains frozen and filled into gelatine capsules that are enteric coated in order that they do not open until the large intestine is reached.

Long before even the advent of antibiotics the Physicians and Microbiologists at that time all understood the role of bacteria in disease but Professor Alfred Nissle had come to recognise that some faecal E.coli isolates showed signs of antagonistic action against pathogens in vitro.

It then becomes quite apparent as to why Nissle was only interested in the soldier who was not affected by dysentery.

The Human Microbiome is made up of all the bacterial colonies on and in the human body. This collection of bacteria numbers some 10 time