RN Labs Folinic Acid 120 capsules
Folinic acid is a pure and hypoallergenic source of metabolically active, yet
unmethylated and therefore less over-stimulating form of folate. Providing a gentle and invaluable basis to folate supplementation for a broad range of clinical applications.
Per bottle: 120 capsules
Product Education:
Active Form. Oral folates are available in a number of supplemental forms. Administration of the folinic acid form bypasses the deconjugation and reduction steps required for the synthetic form, folic acid.
Folinic acid subsequently appears to be a more metabolically active form of folate than folic acid, capable of supporting levels of the coenzyme forms of the vitamin in circumstances where folic acid has little to no effect.
Additionally, folinic acid, as an active but unmethylated form of folate, may be better
tolerated by certain individuals with impediments to folate and methylation metabolism
(including those with MTHFR polymorphisms) if taken in appropriate doses.
Why Folinic Acid over Folic Acid?
In conditions where folate is required, the potentially superior benefits of Folinic Acid
supplementation as a safe, well tolerated and affordable form of folate, may often be
overlooked.
Folinic Acid is well utilised as an immediate precursor to 5, 10-Methylenetetrahydrofolate, the step just prior to the formation of 5-methyltetrahydrofolate (5-MTHF). Oral administration of Folinic Acid therefore bypasses the deconjugation and reduction steps required for the conversion of Folic Acid to 5-MTHF.
Additionally it has been suggested that Folinic Acid might cross the blood brain barrier since reduced folates are actively transported into the brain, whereas Folic Acid on the other hand is poorly transported to the brain and rapidly cleared from the Central Nervous System.
Pure & Free From:
This product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.
Warnings
Medication Interactions: The activity of folinic acid may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.
Folate is considered safe during pregnancy.
Known Side Effects
In doses typically administered for therapeutic purposes, folinic acid is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.
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