Oleoylethanolamide (natural satiety signal)

Name: Oleoylethanolamide (natural satiety signal)
Brand: Designs for Health
Availability: InStock

Weight & Metabolism Powders Designs for Health

Oleoylethanolamide (OEA) is an endogenous lipid mediator produced in the gut after fat ingestion, signalling satiety to the brain via PPAR-alpha and vagal nerve activation. Supports appetite regulation and fat metabolism.

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Summary

OEA is a naturally occurring lipid messenger of satiety. Biologically, OEA has been most extensively characterised for its role in appetite regulation, satiety signalling, and energy balance, with consistent findings across preclinical and clinical studies. Beyond metabolic regulation, emerging research suggests roles in neuroinflammation and neuroprotection, mood regulation and addictive behaviours. These findings are thought to be mediated, at least in part, through activity within the gut-brain axis.

Across diverse clinical populations, OEA has demonstrated consistent efficacy and safety as an adjunctive intervention. Its most robust applications are in appetite dysregulation, excess weight, metabolic syndrome and pre-diabetes, and NAFLD. Additional trials highlight benefits in PCOS, where OEA improves insulin sensitivity and inflammatory tone, and in primary dysmenorrhoea, where its anti-inflammatory and antioxidant actions reduce menstrual pain. Early evidence in acute ischaemic stroke also suggests neuroprotective potential.

Emerging evidence suggests that OEA not only supports intestinal permeability and gut-brain signalling but may also influence the microbial community itself. Preclinical OEA 1 GPR119 L cells GLP-1 Gut lumen Small intestinal epithelium Gastric motility Gastric emptying Food intake Body weight studies indicate that OEA supplementation alters microbial composition.

Beyond its established role in metabolic regulation, OEA has been increasingly investigated for its effects on neuroinflammation and neural integrity, processes central to neurodegenerative and psychiatric disorders, including depression and alcohol-related pathology.

Australia-first supply of Trpti OEA™- a next generation oleoylethanolamide (OEA)

Vegan-friendly

No added gluten, dairy, lactose, soy, or nuts

Dosage

Trpti OEA™ research reference dose: 125 mg twice daily (250 mg per day)

What's in it 1 active ingredient

Oleoylethanolamide (OEA)

Capsule

200 to 400mg daily (practitioner directed)

An endogenous lipid your gut produces after eating fat. Binds to the PPAR alpha receptor to signal satiety, regulate appetite and support fat oxidation. Research supports roles in weight management, metabolic syndrome and non alcoholic fatty liver.

How to take it

As directed by your practitioner. Typically taken 30-60 minutes before meals.

Warnings and important information

Dietary supplements should not replace a balanced diet.

Always read the label and follow directions for use. Vitamins and minerals can only be of assistance if dietary intake is inadequate. If symptoms persist, consult a healthcare professional.