Vitamin K2 supreme
K2 Supreme provides a high-potency MK-7 dose, the most bioavailable, longest-lasting vitamin K2 form, for arterial calcium protection, bone mineralisation and cardiovascular health.
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Product details
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More product information
Designs for Health's K2 Supreme 60 capsules
Supports bone and cardiovascular health
Provides 180 micrograms MenaQ7® (menaquinone 7) per capsule
Supports cardiovascular system health
Supports arterial health
Supports bone mineralisation
Supports bone mass and enhances arterial health in postmenopausal women
Servings per bottle: 60 vegetarian hard capsules
Directions for use Adults: Take one capsule daily with a meal, or as directed by your health professional.
Allergen Information No added: gluten, dairy, lactose or nuts.
Product Education:
Vitamin K2, otherwise known as menaquinone, is part of a group of K vitamers and functions mainly as a cofactor for the post-translational enzyme γ-glutamate carboxylase (GGCX). GGCX is found in the endoplasmic reticulum of a range of mammalian cells and is responsible for the γ-carboxylation of the glutamate residues inherent in around 17 known biological proteins known as Vitamin K Dependent Proteins (VKDPs). Without γ-carboxylation facilitated by K2, these proteins remain inactive and therefore non-functional.
The most heavily researched of the VKDPs affect bone and cardiovascular health. Two of the more well-known of the VKDPs are osteocalcin (OC), involved in the bone-building process and promotes calcification in osseous tissues, and matrix Gla protein (MGP) which acts as a calcium transport molecule in vascular tissues and inhibits vascular mineralisation. Carboxylation of glutamic acid portions on these VKDPs results in the formation of γ-carboxyglutamic acid (Gla), which has an enhanced capacity for the binding of Ca2+ ions. The direct result is optimal calcium mobilisation, storage and metabolism.
K2 can therefore maintain bone health by maintaining optimal mineralisation and support and protect the health of arterial tissues by directing calcium away from the bone rather than vascular tissues.
Chemistry Chemically, the menaquinones have a common methylated naphthoquinone ring structure with a variable aliphatic side chain made up of an assorted number of isoprenoid residues. Menaquinones are named numerically (MK-n) depending upon the length of their isoprenyl side chain, which can contain from 1-14 units. For example, Menaquinone 4 (MK-4) contains 4 isoprenoid units, Menaquinone 7 (MK-7) contains 7 and so on.
MK-7 has been found to be the most bioavailable and have the longest half-life of all of the K vitamers.
Bone Health Osteocalcin (OC) contains three glutamic acid portions that require K2-dependent carboxylation in order to function. Once carboxylated and activated, OC can bind Ca2+ ions and directly incorporate them into hydroxyapatite crystals in the bone matrix.
In a study of 244 postmenopausal women, it was found that over a three-year period, supplementation with 180mcg of Vitamin K2 in the form of MK-7 preserved bone mineral content and reduced age-related losses of bone strength and bone mass.
Artery and Cardiovascul
What's in it
Vitamin K2 (MK-7)
Capsule
Typically 90 to 180mcg
How to take it
Warnings and important information
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