Adaptogen HPA axis blend

RN Labs' Adaptex 60 capsules

Short Dated: End of Nov 2024

Supports healthy stress response in the body

Regulates nervous system and immune system function

Promotes adaptive resilience during times of physical and mental demand

Promotes physical endurance capacity

Promotes mental wellbeing

Can be used in conjunction with laboratory hormone test results (eg. High Cortisol, and/or High Cortisol metabolites)

Suggested use

Adults: Take 1-3 capsules per day or as prescribed by your healthcare practitioner.

Pure & Free From

This product does NOT contain any wheat, gluten, dairy, lactose, egg, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain artificial preservatives, stearate lubricants and other commonly detrimental excipients.

Known Side Effects

Given the potential for Withania and Siberian Ginseng to lower excessive blood sugar levels, monitoring blood glucose in those taking anti-diabetic medications would be prudent.

Rhodiola Rosea has demonstrated CYP450 inhibitory activity. It is therefore recommended to monitor the efficacy of doses of any other co-prescribed medications.

Warning

Avoid use during pregnancy and lactation.

Several studies have shown Withania to support stress adaptation.

In one study, Cortisol levels were reduced compared with placebo, in which participants also showed improvement in sleep quality, while another study trialling Withania for its stress-relieving activity concluded it to have a positive effect in 65 healthy stressed adults.

Results showed statistically significant reductions in the Hamilton Anxiety Rating Scale (HAM-A) and the Depression, Anxiety, and Stress Scale -21 (DASS-21). Reductions in morning Cortisol were also seen.

Gotu Kola has been shown to be effective in attenuating the acoustic startle response (ASR), which may be supportive during times of stress.

Holy Basil (also known as Tulsi), is an indigenous herb to the Indian continent. It has a long history of use in the Ayurvedic System of Medicine as an adaptogen, to improve resilience under ongoing or long-term stress. Many studies have shown favourable clinical outcomes for lifestyle-related chronic maladaptation states

Rhodiola Rosea showed significant benefit in burnout affected patients with stress-related fatigue when compared with the control group.

Exposure to stressors increases Cortisol levels, which is directly associated with physical exhaustion.

During chronic stress where levels of Cortisol are extremely high, the body can experience immune suppression along with muscle wastage and inflammatory responses

One trial revealed Siberian Ginseng to be beneficial for stress adaptation (relative to the control group) when they were subjected to stressful cognitive tasks and experienced a significant improvement in total mood.

Studies:

Withania Somnifera (Withania)

Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozol