Pure Encapsulations NAC 600mg 90 capsules

Pure Encapsulations' NAC (N-Acetyl-l-Cysteine) 600mg 90 capsules

N-Acetyl-l-Cysteine (NAC) is a derivative of the dietary amino acid l-cysteine. NAC has a high affinity for lung tissue, which it supports through mucolytic and antioxidant action. NAC supports tissue levels of glutathione, a key component of the antioxidant defense system.

Per bottle: 90 vegetarian capsules (1 capsule = 1 serving)

Directions for use
Adults: 1 capsule, 1-2 times daily, between meals.

What Is The Source?
Pure Encapsulations N-acetyl-l-cysteine is a free-form amino acid derived from duck feather. The vitamin C (as ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil.

Product Education:

Uses For NAC
Immune And Respiratory System Health: When mucus thickens, it can become difficult to expel. Due to its sulfur content, NAC is able to disrupt disulfide bonds, thinning the mucus so that it, along with the trapped particles and bacteria, are more easily expelled from the lungs. NAC is a powerful free radical scavenger and thus supports epithelial cell health and healthy cilia activity in the respiratory tract. NAC is also a precursor to the antioxidant glutathione. Supplemental NAC increases tissue levels of glutathione. Lymphocytes, specific components of the immune system, rely on glutathione to function properly. Tissues enhanced with glutathione support overall antioxidant protection and help to maintain a healthy immune response. A multicenter, randomized, double blind trial with 262 participants indicated that NAC supplementation for 6 months supported upper respiratory tract and immune system health. A recent meta-analysis of 8 double blind, placebo controlled trials provided additional support for NAC’s ability to support respiratory tract health.

Supports Heavy Metal Detoxification: Several studies suggest that NAC administration to animals may help to reduce mercury and cadmium accumulation in the kidneys and liver and/or to moderate the effects of these metals in these tissues. NAC may achieve these actions in part by facilitating mercury removal from tissues, promoting healthy glutathione levels, or protecting tissues from peroxidation generated by heavy metals.

Are There Any Potential Side Effects Or Precautions?
Rare side effects may include nausea, vomiting, headache, dry mouth, dizziness, or abdominal pain. If pregnant or lactating, consult your physician before taking this product. 

Are There Any Potential Drug Interactions?
NAC may interact with nitroglycerin and metoclopramide. Consult your physician for more information.

Once supplements leave our store they cannot be returned or refunded. Please choose carefully.

Glycine and NAC is an interesting combination:

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks (STUDY LINK)

Glycine and N-Acetylcysteine Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage (STUDY LINK)

A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage (STUDY LINK)

Glutathione is one of the main endogenous antioxidants. Found in virtually every cell of the body's glutathione defends against free radicals, in part by recycling other antioxidants. It also supports detoxification and other critical aspects of cell function.1 Increased glutathione levels have been linked to supporting a reduction in oxidative stress and DNA damage.2 Cysteine and glycine are necessary precursors for glutathione (GSH) synthesis, but the required amounts may not be met by dietary intake alone, particularly as we age.3 Co-supplementation of these nutrients has been shown to promote intracellular glutathione levels.4,5 In a small study involving older individuals, two weeks of supplementation with a combination of N-acety-l-cysteine (NAC) and glycine raised red blood cell (RBC) glutathione levels more effectively than either amino acid alone.5 In one study, supplementation with the combination of NAC and glycine resulted in 32% higher RBC glycine, 46% higher RBC cysteine and a 53% increase in RBC GSH concentration. There was also a significant improvement in the ratio of reduced (active) GSH to oxidized glutathione (GSSG). Increased GSH was associated with improvement in antioxidant status as measured by F2-isoprostanes, as well as mitochondrial fatty acid oxidation.6 In another study comparing young and older subjects, elderly subjects had 55% lower RBC glycine, 24% lower RBC cysteine, and 46% lower RBC glutathione at baseline, as well as lower reduced (active) GSH to GSSG ratios. Supplementation with NAC and glycine in elderly subjects resulted in RBC levels of glycine, cysteine, and glutathione, as well as GSH:GSSG ratio, comparable to young unsupplemented subjects.4 NAC and glycine have been shown to maintain healthy cytokine release during times of metabolic stress.7 Research suggests that glycine may moderate TNFα and promote IL-10 to support cytokine balance, and that glycine intake is positively associated with cardiometabolic health.8 Studies indicate that supplementation with NAC also supports mood and social functioning.9 It is believed that cysteine influences the reward-reinforcement pathway by modulating the glutamate system.10 NAC additionally promotes immune defenses and supports the health of epithelial cells and cilia in the respiratory tract.11 The affinity of NAC for lung tissue, together with its natural sulfur content, allows it to disrupt disulfide bonds within mucus, thinning and easing its expulsion.12 In a randomized, double-blind trial involving mostly older individuals, 600 mg of NAC twice daily showed significant support for respiratory and immune function.13

References

1. Richie JP Jr, et al. Eur J Nutr. 2015 Mar;54(2):251-63.
2. Zhang Q, et al. Medicine (Baltimore). 2018 Nov;97(45)
3. Sekhar RV, et al.Am J Clin Nutr 2011 Sep;94(3):847-53
4. Roes EM, et al. Clin Chem Lab Med. 2002 May;40(5):496-8.
5. Guthikonda, et al. American Geriatrics Society Annual Scientific Meeting, , 2006.
6. Nguyen D, et al. J Clin Endocrinol Metab. 2014 Jan;99(1):169-77.
7. Cruz M, et al. . J Endocrinol Invest 2008 Aug;31(8):694-9.
8. Ding, et al. Circ Cardiovasc Genet. 2016 Dec;9(6):541-547.
9. Berk M, et al. Biol Psychiatry. 2008 Sep 15;64(6):468-75.
10. Grant JE, et al. Arch Gen Psychiatry. 2009 Jul;66(7):756-63
11. Ozdemir ZC, et al.Hemoglobin. . 2014;38(5):359-64.
12. Tse HN, et al. Chest. 2013 Jul;144(1):106-18
13. De Flora S, et al. Eur Respir J J. 1997 Jul;10(7):1535-41.