GeneType Risk Test

GeneType Risk Test Kit

• Have a better idea of your disease risk 
• Personalized risk score. Personalized health plan.
• Simple saliva collection 
• Clinically actionable results
• Genetic Counselor post-test consultation available 

Laws may not protect against genetic discrimination in all circumstances or in the future, for example when applying for life insurance or disability insurance.

The GeneType test covers genetic and lifestyle factors to provide an advanced integrated risk assessment. This can allow more informed decision-making discussion about individualized screening strategies, lifestyle management and more. Healthcare providers can then optimise your personalised healthcare plan.

GeneType reports help you and your health provider translate your personal clinical, family and genetic data into an actionable preventive health plan.

Be more proactive about your health and understand risk from a more comprehensive viewpoint. For example, 1 in 5 women will have a combination of risk factors that put them at an actionable, increased risk (using established clinical thresholds 5-year risk threshold of 1.67% or 3%; lifetime risk threshold of 20%).

The test includes ALL the following for 1 patient:

Breast Cancer- lifetime and 5-year risk scores. The test integrates common genetic factors with traditional risk markers to provide highly personalized – and actionable – risk predictions. This test does NOT look for hereditary germline pathogenic variants like BRCA. This is a risk assessment for patients that either do not qualify for hereditary testing, or who have received negative germline hereditary cancer panel results. Hereditary genetic testing is the tip of the iceberg in breast cancer risk assessment. Although impactful, it only affects a small proportion of your patient population. The remainder of the population is still at risk of sporadic (non-hereditary) breast cancer; this test can help identify a group of at-risk patients that may have otherwise “flown under the radar.”

If you are 30 years of age and answered yes to having any of these risk factors it is worth considering getting tested. On their own, each risk factor adds only a small amount of risk to your chances of developing breast cancer. Together, they may increase your risk to a point where a proactive approach is recommended.

How many of these questions can you answer yes to?

• I am 30 or older
• I have been told I have dense breast tissue
• I have not had a mammogram within the past year
• I have a relative who has had breast cancer
• I have taken (am taking) oral contraception
• I gave birth to my first child after 30
• I did not breastfeed
• I have been taking hormone replacement therapy
• I have started menopause
• I’ve gained post-menopausal weight
• I want to understand my “baseline” genetic risk

Does the GeneType look for hereditary mutations in genes like BRCA1?
No! This risk assessment is for women either do not qualify for hereditary testing OR who have already tested negative for hereditary pathogenic variants (aka mutations) in genes like BRCA1/2. The majority of women will not be carriers of these types of hereditary mutations, but will still be at risk of developing breast cancer. GeneType helps to better identify the women that are at risk of “flying under the radar.” To understand your risk of developing sporadic (non-hereditary) breast cancer, geneType can help.

GeneType for Breast Cancer is the only test that gives you a comprehensive and highly accurate risk prediction score based on:

• Your own genetic markers of breast cancer risk
• Your age
• Your family history of breast cancer (if any)
• Your body mass index
• Your breast density from your last mammogram (if available)
• Your menopausal status

Risk reduction strategies could include:

• Mammography (digital, tomosynthesis)
• MRI
• Ultrasound
• Breast cancer prevention specialist referral
• Medication aromatase inhibitors; selective estrogen receptor modulators
• Diet and exercise modifications
• Smoking cessation
• Alcohol consumption modification

Colorectal Cancer - lifetime and 10-year risk scores. Most colorectal cancers occur in people with no significant family history because many factors can increase your risk of developing colorectal cancer such as age, genetics, family history, inherited syndromes, ethnicity, weight, physical activity, alcohol intake, diet, and smoking.

GeneType for Colorectal Cancer is the only test that combines the following to give you a holistic and highly accurate risk prediction score based on:

• Common genetic markers of colorectal cancer risk
• Your age
• Your family history of colorectal cancer (if any)

Important! geneType does not replace your routine screening; consider starting colonoscopy screening at age 45.

GeneType identifies asymptomatic, healthy adults who are at increased risk of developing colorectal cancer. Only ~30% of colorectal cancer patients have some family history or hereditary genetic risk of the disease. GeneType improves upon traditional risk assessment.

Must be aged 30 – 85 years. Exclusion criteria include a personal history of CRC, carrier of a known hereditary cancer syndrome (i.e. Lynch or FAP). geneType does not test for hereditary cancer syndromes

Depending on your risk, your healthcare provider may discuss some or all of the following:

• Cancer prevention specialist/high risk center referral
• Additional screening (colonoscopy, FIT fecal immunochemical test, FOBT fecal occult blood test)
• Medication
• Diet and exercise modifications
• Smoking cessation
• Alcohol consumption modification

Ovarian Cancer - lifetime and 10-year risk scores. GeneType for Ovarian Cancer is for: Women Aged 30 years or older without known hereditary breast and ovarian cancer (HBOC) gene mutation e.g. BRCA1 or BRCA2

It factors in genetic risk factors, age, ethnicity, hormonal medication, menopausal status, parity, past oophorectomy.  

Prostate Cancer - lifetime and 5-year risk scores. Current PSA screening recommendations take into account your age, ethnicity and family history. Want to know what role your underlying genetic risk plays? GeneType prostate risk score can provide greater insight. Must be a man aged 30-85 years with no known hereditary gene mutation e.g. BRCA2.

Pancreatic Cancer - lifetime and 10-year risk scores. Cancer is a multifactorial disease and there are many different risk factors. Of these, GeneType integrates the most predictive risk factors into the model. Future models may include additional risk factors as the scientific community’s understanding of pancreatic cancer continues to evolve. Must be 30-85 years old with no known hereditary syndrome carriers e.g. CDKN2A, BRCA1.

Melanoma- lifetime and 10-year risk scores. This integrated risk assessment includes things like tanning bed use, skin/hair colour, genetic risk factors, number of naevie. Must be 30-85 years old, and have not be a carrier of a known hereditary syndrome e.g. CDKN2A

Also includes: Coronary Artery Disease - 10-year risk score
 and Type 2 Diabetes - 8-year risk score for type 2 diabetes

• You need to be an existing patient to order this test, please discuss it with your doctor first, please ensure you read this page carefully to ensure you are eligible for the test
• If you are a doctor at another practice and want to offer this test to your patients they can order and see you instead of us, please ensure you refer them or contact us first.
• If you are high risk you will also receive free genetic counselling by the experts at GeneType 

Summary of eligibility criteria

Cancers:
- 30-85 years of age
- not a pathogenic mutation carrier
- never been diagnosed with the disease prior

Cardiovascular and type 2 diabetes:
- 40-85 years of age
- not a pathogenic mutation carrier
- never been diagnosed with the disease prior
- These tests require recent blood pressure and lipid panel results from within 6 months specifically, for atrial fibrillation: systolic blood pressure, for coronary artery disease: HDL, blood pressure and total cholesterol level, for type 2 diabetes: fasting glucose, triglyceride, HDL and blood pressure.


Benefits of a geneType risk assessment test
geneType is different to traditional risk assessments as it integrates a risk factor signature within a patients’ DNA known as a polygenic risk score. This additional risk factor is valuable when combined with other clinical risk factors that we look at to predict chances of developing disease.

Following a geneType test, the doctor will provide the patient with a personalised Test Report. This report provides greater understanding of the risk of getting the disease the patient was screened for, over a short time frame and over their lifetime. These reports can facilitate joint-decision-making- discussions around screening and risk-reduction options individualised to each patient's needs.

By ordering you acknowledge the test is intended for research, educational, and informational use only. Discuss results with your healthcare provider.