Designs for Health OEA (Oleoylethanolamide)

Summary

OEA is a naturally occurring lipid messenger of satiety. Biologically, OEA has been most extensively characterised for its role in appetite regulation, satiety signalling, and energy balance, with consistent findings across preclinical and clinical studies. Beyond metabolic regulation, emerging research suggests roles in neuroinflammation and neuroprotection, mood regulation and addictive behaviours. These findings are thought to be mediated,  at least in part, through activity within the gut-brain axis.

Across diverse clinical populations, OEA has demonstrated consistent efficacy and safety as an adjunctive intervention. Its most robust applications are in appetite dysregulation, excess weight, metabolic syndrome and pre-diabetes, and NAFLD. Additional trials highlight benefits in PCOS, where OEA improves insulin sensitivity and inflammatory tone, and in primary dysmenorrhoea, where its anti-inflammatory  and antioxidant actions reduce menstrual pain. Early evidence in acute ischaemic stroke also suggests neuroprotective potential.

Emerging evidence suggests that OEA not only supports intestinal permeability and gut-brain signalling but may also influence the microbial community itself. Preclinical OEA 1 GPR119 L cells GLP-1 Gut lumen Small intestinal epithelium Gastric motility Gastric emptying Food intake Body weight studies indicate that OEA supplementation alters microbial composition. 

Beyond its established role in metabolic regulation,  OEA has been increasingly investigated for its effects on neuroinflammation and neural integrity — processes central to neurodegenerative and psychiatric disorders, including depression and alcohol-related pathology.

• Australia-first supply of Trpti OEA™- a next generation oleoylethanolamide (OEA) 
• Vegan-friendly 
• No added gluten, dairy, lactose, soy, or nuts