{"product_id":"nutripath-cortisol-rhythm-and-sex-hormones-at-home-saliva","title":"Cortisol rhythm and sex hormones (at-home saliva)","description":"\u003ch2 class=\"product-marketing-headline\"\u003eMeasure your stress and sex hormones without leaving home\u003c\/h2\u003e\u003cp class=\"product-tagline\"\u003e\u003cem\u003eA four point cortisol rhythm with sex hormones, collected from saliva at home. Shows how stress and hormones interact across your day.\u003c\/em\u003e\u003c\/p\u003e\u003cp class=\"product-brand-attribution\"\u003eTest processed by \u003cstrong\u003eNutriPath\u003c\/strong\u003e\u003c\/p\u003e\u003cdiv class=\"product-short-description\"\u003e\u003cp\u003eAn at home saliva test that captures cortisol at four points across the day (on waking, noon, evening, bedtime) alongside oestradiol, progesterone, testosterone and DHEA. Gives you the rhythm as well as the level. Best for anyone experiencing fatigue, sleep disturbance, PMS or perimenopausal symptoms.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"product-long-description\"\u003e\u003cp\u003eA single blood cortisol measurement tells you almost nothing, because cortisol is supposed to rise and fall across the day. What matters is the rhythm. This saliva panel captures four cortisol readings at the biologically meaningful points (shortly after waking, noon, evening and bedtime) alongside your free bioavailable sex hormones (oestradiol, progesterone, testosterone) and DHEA. The rhythm tells you whether your HPA axis is responding appropriately to daylight and stress or whether it has flattened, reversed or become erratic. The sex hormone layer shows you how your reproductive hormones sit in the context of your stress response, a distinction that is often missed in single point testing. Completed at home over one day and mailed in a prepaid envelope.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"product-ingredients\"\u003e\n\u003ch3\u003eWhat it measures\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eBiomarker\u003c\/th\u003e\n\u003cth\u003eSample\u003c\/th\u003e\n\u003cth\u003eReference Range\u003c\/th\u003e\n\u003cth\u003eWhat it tells you\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCortisol (x4 points)\u003c\/td\u003e\n\u003ctd\u003eSaliva\u003c\/td\u003e\n\u003ctd\u003eWaking peak, gradual decline to near zero at bedtime\u003c\/td\u003e\n\u003ctd\u003eThe four point rhythm is far more informative than any single cortisol reading. Reveals flattening (burnout pattern), reversed rhythm (high at night, low in morning) or elevation at specific times.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDHEA\u003c\/td\u003e\n\u003ctd\u003eSaliva\u003c\/td\u003e\n\u003ctd\u003eDeclines with age, low in chronic stress\u003c\/td\u003e\n\u003ctd\u003eThe adrenal hormone that counter balances cortisol. Low DHEA with elevated cortisol is the classic chronic stress pattern.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOestradiol (E2)\u003c\/td\u003e\n\u003ctd\u003eSaliva\u003c\/td\u003e\n\u003ctd\u003eMeasures bioavailable oestrogen\u003c\/td\u003e\n\u003ctd\u003eSaliva reflects free, unbound oestradiol, which is the biologically active fraction.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eProgesterone\u003c\/td\u003e\n\u003ctd\u003eSaliva\u003c\/td\u003e\n\u003ctd\u003eMeasures bioavailable progesterone\u003c\/td\u003e\n\u003ctd\u003eThe free fraction of progesterone, which correlates with symptoms more reliably than total serum levels.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTestosterone (Free)\u003c\/td\u003e\n\u003ctd\u003eSaliva\u003c\/td\u003e\n\u003ctd\u003eMeasures active testosterone\u003c\/td\u003e\n\u003ctd\u003eWomen produce testosterone too. Low free testosterone is associated with low libido, low mood and reduced muscle mass.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eProgesterone:Oestradiol Ratio\u003c\/td\u003e\n\u003ctd\u003eCalculated\u003c\/td\u003e\n\u003ctd\u003eContext dependent\u003c\/td\u003e\n\u003ctd\u003eOne of the most useful ratios in assessing perimenopausal symptom drivers. Low progesterone relative to oestradiol often explains PMS, sleep and mood symptoms in the late 30s and 40s.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-how-to-take\"\u003e\n\u003ch3\u003eHow to collect and what to expect\u003c\/h3\u003e\n\u003cp\u003eCompleted at home. Collect saliva samples on a single day at: 30 to 60 minutes after waking, 12pm, 5pm, and bedtime. Avoid brushing teeth, eating, drinking coffee or exercising in the 30 minutes before each collection. Return samples in the prepaid envelope. Results in 7 to 10 business days.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-warnings\"\u003e\n\u003ch3\u003eWarnings and cautions\u003c\/h3\u003e\n\u003cp\u003eThis is a health information test. Do not make clinical decisions about corticosteroid medication based on these results. Saliva hormone levels are suppressed by oral hormone replacement therapy taken on the day of collection. Discuss results with a hormone focused practitioner for interpretation.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-faqs\"\u003e\n\u003ch3\u003eCommon questions\u003c\/h3\u003e\n\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eWhy saliva over blood for this panel?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eSaliva measures the free, bioavailable fraction of cortisol and sex hormones. Blood measures both bound and free hormone. For assessing rhythm (cortisol across the day) and biological activity, saliva is the standard in functional medicine for good reason.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eDoes this test adrenal fatigue?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eAdrenal fatigue is not a medically recognised diagnosis. What this test does show is whether your cortisol rhythm has flattened or become disrupted, which is a real and measurable phenomenon. Interpretation requires a practitioner who understands the HPA axis.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eI am on HRT, can I test?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eOral HRT taken on the day of collection will affect saliva oestradiol and progesterone readings. Either test on a day when you hold your morning dose (discuss with prescriber first) or interpret the results in the context of your dosing.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eWhen should I collect during my cycle?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eDay 19 to 22 (mid luteal phase) is optimal for a baseline pattern. If cycles are absent or highly irregular, any day is acceptable.\u003c\/p\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-clinical-evidence\"\u003e\n\u003ch3\u003eClinical evidence\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19041658\/\" target=\"_blank\" rel=\"noopener\"\u003eSalivary cortisol in research and clinical practice\u003c\/a\u003e: Review of salivary cortisol as a validated biological sample for HPA axis assessment.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26361809\/\" target=\"_blank\" rel=\"noopener\"\u003eCortisol awakening response in clinical settings\u003c\/a\u003e: The cortisol awakening response as a reliable marker of HPA axis function.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18854068\/\" target=\"_blank\" rel=\"noopener\"\u003eSalivary sex hormone measurement\u003c\/a\u003e: Evidence base for salivary sex hormone measurement as a reflection of bioavailable hormone.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"NutriPath","offers":[{"title":"Default Title","offer_id":52591883092242,"sku":"OPTI-NUTRIPATH-CORTISOL-RHYTHM-AND-SEX-HORMON","price":342.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0557\/2087\/0083\/files\/nutripath-cortisol-rhythm-and-sex-hormones-at-home-saliva.jpg?v=1786431182","url":"https:\/\/optilabs.com.au\/products\/nutripath-cortisol-rhythm-and-sex-hormones-at-home-saliva","provider":"OptiLabs by Evergreen Doctors","version":"1.0","type":"link"}