{"product_id":"nutripath-coeliac-disease-blood-screen","title":"Coeliac disease blood screen","description":"\u003ch2 class=\"product-marketing-headline\"\u003eThe complete coeliac disease screen, not just the one marker\u003c\/h2\u003e\u003cp class=\"product-tagline\"\u003e\u003cem\u003eThe complete coeliac serology panel. Essential for anyone with unexplained gut symptoms, fatigue, nutrient deficiencies or a family history of coeliac disease.\u003c\/em\u003e\u003c\/p\u003e\u003cp class=\"product-brand-attribution\"\u003eTest processed by \u003cstrong\u003eNutriPath\u003c\/strong\u003e\u003c\/p\u003e\u003cdiv class=\"product-short-description\"\u003e\u003cp\u003eMeasures all four antibody markers recommended for coeliac disease screening: tissue transglutaminase IgA and IgG (tTG), deamidated gliadin IgA and IgG (DGP), and total IgA (to rule out IgA deficiency that can cause false negatives).\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"product-long-description\"\u003e\u003cp\u003eCoeliac disease affects approximately one in 70 Australians but remains substantially underdiagnosed. Many people spend years with unexplained fatigue, iron deficiency, gut symptoms, osteoporosis or infertility before the coeliac connection is identified. Complete coeliac serology is the first step in diagnosis. Tissue transglutaminase (tTG) IgA is the primary screening marker, with sensitivity around 95 percent when gluten is in the diet. Deamidated gliadin peptide (DGP) antibodies add sensitivity in seronegative or paediatric cases. Total IgA is essential to check, because one in 400 people have selective IgA deficiency, which will produce a false negative on IgA based coeliac tests and requires IgG testing instead. This complete panel captures all four markers so no pattern is missed. Critically, you must be consuming gluten for at least 6 weeks before testing, or results will be falsely negative.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"product-ingredients\"\u003e\n\u003ch3\u003eWhat it measures\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eBiomarker\u003c\/th\u003e\n\u003cth\u003eSample\u003c\/th\u003e\n\u003cth\u003eReference Range\u003c\/th\u003e\n\u003cth\u003eWhat it tells you\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eTissue Transglutaminase IgA (tTG IgA)\u003c\/td\u003e\n\u003ctd\u003eBlood (SST)\u003c\/td\u003e\n\u003ctd\u003eUnder 20 U\/mL negative\u003c\/td\u003e\n\u003ctd\u003eThe primary coeliac screening antibody. Highly sensitive and specific when gluten is in the diet.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTissue Transglutaminase IgG (tTG IgG)\u003c\/td\u003e\n\u003ctd\u003eBlood (SST)\u003c\/td\u003e\n\u003ctd\u003eUnder 20 U\/mL negative\u003c\/td\u003e\n\u003ctd\u003eUsed in people with IgA deficiency to avoid false negatives on the IgA based test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDeamidated Gliadin Peptide IgA (DGP IgA)\u003c\/td\u003e\n\u003ctd\u003eBlood (SST)\u003c\/td\u003e\n\u003ctd\u003eUnder 20 U\/mL negative\u003c\/td\u003e\n\u003ctd\u003eAdds sensitivity, particularly in children and in seronegative coeliac disease.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDeamidated Gliadin Peptide IgG (DGP IgG)\u003c\/td\u003e\n\u003ctd\u003eBlood (SST)\u003c\/td\u003e\n\u003ctd\u003eUnder 20 U\/mL negative\u003c\/td\u003e\n\u003ctd\u003eThe most useful marker in IgA deficient individuals.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal IgA\u003c\/td\u003e\n\u003ctd\u003eBlood (SST)\u003c\/td\u003e\n\u003ctd\u003eWithin reference range\u003c\/td\u003e\n\u003ctd\u003eEssential context. IgA deficiency affects 1 in 400 people and will produce false negative results on IgA based coeliac tests.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-how-to-take\"\u003e\n\u003ch3\u003eHow to collect and what to expect\u003c\/h3\u003e\n\u003cp\u003eYou must be consuming gluten regularly (at least 2 slices of bread or equivalent daily) for 6 weeks before testing. Testing gluten free will produce a false negative. No fasting required. Book at any NutriPath referral centre. Results in 3 to 5 business days.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-warnings\"\u003e\n\u003ch3\u003eWarnings and cautions\u003c\/h3\u003e\n\u003cp\u003eThis is a health information test. Positive serology requires confirmation by small bowel biopsy (upper endoscopy with duodenal biopsy) for definitive coeliac diagnosis. Do not go gluten free based on positive serology alone, as this makes confirmatory biopsy more difficult. Discuss positive results with a GP or gastroenterologist.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-faqs\"\u003e\n\u003ch3\u003eCommon questions\u003c\/h3\u003e\n\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eI am already gluten free. Can I still test?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eNot reliably. If you have been gluten free for more than 2 weeks, both serology and biopsy become unreliable. A gluten challenge of 6 weeks minimum (2 slices of bread per day) is usually required before testing. Discuss with a GP or gastroenterologist.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eWhat if serology is positive but I feel fine?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eSome people with coeliac disease have minimal symptoms but still have intestinal damage and long term risk (osteoporosis, nutrient deficiencies, elevated lymphoma risk, pregnancy complications). Positive serology warrants confirmatory biopsy even without overt symptoms.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eDo I need a biopsy if serology is positive?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eCurrent Australian gastroenterology guidelines recommend biopsy confirmation before a definitive diagnosis in adults. There are moving discussions about no biopsy diagnosis in very high titre cases, but this is a specialist decision.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003e\u003cstrong\u003eIs gluten sensitivity different from coeliac disease?\u003c\/strong\u003e\u003c\/summary\u003e\u003cp\u003eYes. Non coeliac gluten sensitivity is a real but separate phenomenon with negative coeliac serology and negative biopsy but symptom response to gluten removal. Diagnosis is clinical, by exclusion and reintroduction challenge.\u003c\/p\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-clinical-evidence\"\u003e\n\u003ch3\u003eClinical evidence\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.gesa.org.au\/education\/clinical-updates\/coeliac-disease\/\" target=\"_blank\" rel=\"noopener\"\u003eAustralian coeliac disease clinical guidelines\u003c\/a\u003e: GESA guidelines on coeliac diagnosis and serology interpretation.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25521478\/\" target=\"_blank\" rel=\"noopener\"\u003eCoeliac serology sensitivity and specificity\u003c\/a\u003e: Performance characteristics of tTG, DGP and total IgA in clinical practice.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22002579\/\" target=\"_blank\" rel=\"noopener\"\u003eSelective IgA deficiency and coeliac testing\u003c\/a\u003e: Why total IgA is essential when coeliac serology is run.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"NutriPath","offers":[{"title":"Default Title","offer_id":52591877456146,"sku":"OPTI-NUTRIPATH-COELIAC-DISEASE-BLOOD-SCREEN","price":274.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0557\/2087\/0083\/files\/optilabs-coeliac-screen-blood.png?v=1786431160","url":"https:\/\/optilabs.com.au\/products\/nutripath-coeliac-disease-blood-screen","provider":"OptiLabs by Evergreen Doctors","version":"1.0","type":"link"}